From St. Louis:

Take I-70 to the Highway 79 exit in St. Peters. Go north on Highway 79 until you reach Louisiana, MO. You'll find The Eagle's Nest at the intersection of Highway 79 (in Louisiana it is called 3rd Street) and Georgia St on the northeast corner.

From Kansas City:

Take I-70 east to the Highway 54 exit (at Kingdom City). Stay on Highway 54 until you reach Louisiana, MO. Highway 79 will be the last turn to your right before you cross the Mississippi River bridge. Turn south on Highway 79. You'll find The Eagle's Nest at the intersection of Highway 79 (in Louisiana it is called 3rd Street) and Georgia St on the northeast corner.

From Springfield:

Take I-72 west to Highway 54. Head south on Highway 54 until you cross the Mississippi River bridge. The first left past the bridge is Highway 79; turn left and head south. You'll find The Eagle's Nest at the intersection of Highway 79 (in Louisiana it is called 3rd Street) and Georgia St on the northeast corner.